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Prostate cancer prevention
In women of reproductive age, the most effective screening test for prescription drug prices us vs canada risk of prostate cancer is clinical PSA testing. There are about 5.5 million new men of reproductive age admitted annually to emergency departments with a diagnosis of prostate cancer. Men ages 50 years and older account for about 70 percent of all diagnosed prostate cancers in men and 85 percent of them are incurable.1,2 The American Cancer Society estimates that one of every six cancers in male cancer patients is incurable and one-fourth of all prostate cancer deaths occur in men between the ages of 50 and 83 years old. These stats are based on data from more than 3 million medical records.2,3
Although PSA levels are relatively low, some young healthy men (aged 18 to 24 years) are at a higher risk for developing prostate cancer compared with older age groups.1,4 For example, PSA levels can be high in men between the ages of 25 to 30 years but only 10 percent of men in this age range are clinically confirmed to have a specific type of prostate cancer. According to the National Comprehensive Cancer Network, men between the ages of 30 to 39 years and older are 2.7 times more likely to develop prostate cancer than men in this age group, group are 5.8 times more likely to develop prostate cancer and men age 40 years older are 4.8 times more likely to develop prostate cancer.3 A recent study in the US showed that almost half of all prostate cancers diagnosed among young men were not treated because of poor PSA response (PSA <500 nmol/L).5 It also demonstrated that in patients with PSA levels of 2.5 ng/mL or lower, median survival was 1.8 years when treated as early the third year after diagnosis.6,7 It is interesting to note that a positive PSA test in older men has been shown to have an elevated risk of mortality.7
PSA is one of the most common and well established screening tests for prostate cancer. Although testing by PSA and digital rectal exam (DRE) do not test for the full range of human prostatic carcinoma, they do provide a quick, noninvasive way to screen for prostate cancer. While the DRE is considered to be the gold standard for prostate cancer diagnosis, both the PSA and DRE tests have been shown to be highly predictive of clinical disease ( ).8 PSA is also more sensitive to detect early stages of prostate cancer than the DRE.9 These facts make PSA an excellent screening test and are why researchers clinicians choose it as the best choice to screen for prostate cancer in young men as well older men.
DRE results from digital rectal exam are less accurate than PSA in younger men.10 While there have been some studies showing that PSA is more sensitive in older men, no definitive studies have shown that the DRE is any more sensitive than a PSA test.7
The results of prostate cancer screening test, the specific antigen (PSA) and digital rectal exam (DRE) are summarized in. Patients will typically be offered the PSA test at screening, and will be given an option to opt for the DRE or not. PSA test is a more sensitive than the DRE test because it is able to detect early stages of prostate cancer in the early stage without any biopsy.11 Therefore, it can provide a more reliable and quick way to determine whether a cancer is stage I (non)
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Cotrimoxazole dose for prophylaxis and therapy the treatment of uncomplicated gram-negative sepsis. Clin Infect Dis 1995 13: 805-821. 2. Poulsen, M. et al. Antimicrobial susceptibility of S. aureus strains associated with surgical wound infections in a Danish population. Antimicrob Agents Chemother 1991 29 Suppl 10: 679-686 3. LeBaron, S. Bacteriocins, Antimicrobial Activity and Effectiveness. Clinical Pharmacal Toxicology Therapeutics 1989 8: 61-73. 4. Lee, H. S. and K. Kwon. Antimicrobial activity, potency and response of new synthetic agents and other plant drug components. In W. A. Wollenberg, S. G. Dye, and D. J. Smith (Eds.) Antimicrobial compounds: biology, chemistry and drug delivery. Plenum Press, New York (1990) pp 3-28. 5. Geller, D. K. et al. Evaluation of bactericidal activity natural products against methicillin resistant Staphylococcus spp. Clinical Microbiology and Infectious Disease 1993 30(Suppl 3) p S4. 6. Poulten, G. et al. Inhibition of the colonization Gram-negative, non-spore forming strains by nalidixic acid. Antimicrob Agents Chemother 1985 28: 2139-2143. 7. Gantz-Streckner, V. and B. J. Rundblad. Antimicrobial activity of the essential oil component, nigrum dulcificum in vitro. Antimicrob Agents Chemother 1996 34: 30-44. 8. Bocci, R., L. Vizzeri, and M. Vizzeri. In vitro antibacterial activity of a few aromatic compounds. adderall generic brands barr European Journal of Pharmacology 1995 51, S63-S67. 9. Vittin, I. V., P. De Gennaro, and C. Marraffino. A comparison of bactericidal activity and antimicrobial two compounds from Lavandula angustifolia and its active component lavandin-4-(3-carboxy-3-pentyloxyphenyl)-7-sulfates. Microbial Biotechnology and Antimicrobial Technology 1997 14: 23-28. 10. Rundgren, C. E and D. Völker. An in vitro inhibition of Gram positive and negative bacteria yeast in the presence of essential oil. J. Microbiol. 1966 26: 397-406. 11. Vittin, I. V and P. De Gennaro. Comparison of bacterial and yeast bioactivity following treatment with essential oils. Clinical Microbiology and Infectious Disease 1991 31:S31-S36. 12. Fuchs, W. and J. Bacher. Influence of essential oils on a variety of microorganisms. In C. D. Brown, S. B. Strain (Eds.) Biotechnology of essential oils and other plant components (Chapel Hill : University of North Carolina Press, 1997) pp. 21-34. 13. Fuchs, W. and J. Bacher. The effect of phenolics in extract Lavandula angustifolia on microorganisms grown in vitro: Comparison to inorganics. Biotechnology of Essential Oils and Other Plant Compounds 1996 15: 151-166. 14. Matsuura, H., H. Sato and Yamamoto. Phenolic, antimicrobial antitumor agents from plant oils - the case of lavender. Jpn J. Pharmacol. 1985 28: 1445-1449. 15. Kondo, Y. et al. Effect of lavender essential oil and carvacrol extract on Listeria innocua. best generic adderall ir brand FEMS Microbiol Lett. 1989, 111: 1-3. 16. Lee, B. T. and S. K. Moon. Comparative toxicity of essential oils and plant extracts against Escherichia coli, Salmonella enterica and Bacillus cereus in vitro. Food Microbiol. 1994, 31: 461-467. I would also like to thank my students at Loma Linda University Medical Center (Loma Linda). © Loma Linda University School of Medicine and Biomedical Sciences, All Rights Reserved.
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